Abstract Background Most proteins function by interacting with other molecules.Their interaction interfaces are highly conserved throughout evolution to avoid undesirable interactions that lead to fatal disorders in cells.Rational drug discovery includes computational methods to identify the interaction sites of lead compounds to the target molecul
Abstract Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy.The replication competent latent HIV reservoir has click here been quantified with the terminal dilution quantitative viral outgrowth assay, which induces virus propagation in CD4+ T cell culture supernatants following cell
Metro accidents are apt to cause serious consequences, such as casualties or heavy economic loss.Once accidents occur, quick and accurate decision-making is essential to prevent emergent accidents from getting worse, which remains a challenge due to the lack of efficient knowledge representation and retrieval.In this research, an ontological method
The 3rd millennium BC appears to be a key period of development of the historical settlement landscape in ancient Egypt.After the unification of the country, the process of disappearance of the predynastic socio-political structures and settlement patterns associated with them significantly accelerated.Old chiefdoms, along with their centres and el